The excerpts below from the manufacturers' Prescribing . My 6 year old Chihuahua has been on simparica trio for 4 days . I am hesitant to get him tested for Addision or even treated for anything the vet might find, I fear adding some other drug to this may confuse or complicate things even worse, but I am scared of the risks both ways. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewablefor protection against: . Then a week later 2 more just 24 hours apart then a little over w week later she had 3 in 24 hours. Use topical or a collar if you are concerned. My Irish setter is weak on her left side, left side of her face is drooping and she now carries her head with a tilt to the left. I to also gave my best friend Simparica as recommended by the vet. Would appreciate any opinion you all may have. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). Linda. I have noticed that recently he seems to stumble a little from time-to-time. It is the flea and tick component that is the problem. I have paid about $500 - $600 to heal the little King, but it's not working. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! I thought maybe my dog had a bladder infection or got into something that upset her gut. Anyway, he prescribed him pain relief for 7 days. So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. I guarantee he will not take this trash again. Bella continues to drink in excess of normal amounts. We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. Is it too late? Advised I could call Simparica for reimbursement or to report side effects. He also got that odd cough here and there that I read someone else mention. Ive read these stories and am also disgusted. Hoping for good news with your pup!! And my 1 year old cockapoo has been having regular seizures and her blood work has come back indicative of liver dysfunction. I dont know what to do to get this out of their system?? Our dog was killed by this poison within 15 hours after taking one dose. My dog is 9 yrs old . Hi, Im having similar issues. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. The costs associated with these two products are roughly the same. I will post an update 7 days later. She hasnt had any more seizures but still seems off. My poor puppy has to go under anesthesia on top of. And how do we get the word out to everyone? She has been treated by this clinic since birth. Can blocking GABA receptors also cause inflammation of spine? All antiparasitics for dogs lower the seizure threshold. How can you give a dog a pesticide to ingest. The issues started within 24 hours of the dose and continue. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. Gave our 23 month old Black Lab. And it looks like the liver and/or the kidney will not take it too. just gave my one year old dauchund her first dose of simparica My vet didnt tell me, We gave our Yorkie this and she went into seizures later in the daywhat if any thing can be done. Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! I am sure simparica caused a fatal seizure in my boxer. No appetite, not like Charlie. He had it once before with no issues. I do believe it caused her blindness. This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). Tell your veterinarian if your dog has a history of seizures or other neurologic disease. He also lashes at me with his teeth. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. She went on 2 antibiotics, and medicated baths twice a week. She walks around as if she is on ice with no control of her back legs. The Simparica chewable is a poor choice for dogs with a history of prior seizures. I never saw a flea because he has a very thick coat. Different vet. I also am seeking information as to if there is a class action suit against this company because there should be. Back to the vet and I hope they credit my money. The reason I had stopped it , I saw a Instagram where a girls dog took the. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. She was terrified and we were too. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. The following day she got diarrhea and was extreemly quiet. PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs), 6 Doses. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). He has been eating the same organic GF food for the past several years. The most common side effects of Simparica in dogs are vomiting and diarrhea. I hope it is better. Her blood work came back fine. Has anyone else experienced this? The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. I cant believe how long this thread is. Started in February and within a couple of weeks ears started twitching. The vet does not feel it is due to Simparica but i think it could be. Sarolaner is also used in combination products for both dogs and cats. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . Today shes been panting. Vets at Petsmart should know better; changing vets. Hi Charlene, can you elaborate on agitated swallowing? Hoping you are the lucky ones!! My heart is broken. I dont like the idea if ingestible medicine that kills fleas. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. Yesterday one baby threw up four times within one hour of taking her chewable. Any advice on the diarrhea? We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. The king cavalier bichon mix seems to be ok just not eating much if at all. RELATED: Signs Your Dog Might Be Having a Seizure. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. She is still in the vet since 3am. 98. Sometimes I think he is either blind or deaf. I just wanted them gone and for him to feel better. I have ordered what I normally use and will throw this in the trash! But I have heard of other dogs who recover, or who continue having seizures but not fatal. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. I have had German Shepherds for 40 yrs. I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. On Jan 4th for the first time. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I finally got him to eat some chicken and he threw that up 2 hours later. My wife and I didn't understand why. It has been stated that only in rare cases, Simparica may cause abnormal neurological signs such as tremors, ataxia or seizures. Instead it has become a world of greed. I am hoping it is almost all out of her system. She has been very unpredictable and snapping at people but this is improving. I am so worried about her! Now do you get the connection? Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. I just almost had a similar incident with my 16wk cavapoo. I do know that she was a healthy and somewhat energetic 10 year old before the treatment. He seems sometimes anxious and is sensitive to noise outside. Now that Ive read all these comments I think he has developed these issues because of this trio medication. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. supply) at Chewy.com. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. I could never forgive myself. Im wondering if anyone else has seen these types of symptoms. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. This happened the same to my dog.. how si going now with your pet? I'm so angry this medication is on the market. Shame on you! His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. I will be discontinuing the medication. I fell like hes dying right before my hands. Or has it been too many doses ? Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. We asked our vet, but he ignored the question. Simparica Trio is just one of many parasite prevention products on the market for dogs. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. The Vet's are so busy that even if you can get in you don't get anywhere. She's a Brittany (Spaniel). It all depends, sadly. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. So you can imagine my worry now. I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. I gave my black lab mix Simparica for the 1st time on 4/1. Seizure meds arent working. Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs and young puppies. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. I would, still boil chicken, carrots, potatoes for his meals. Sadly and heartbroken I report a follow up that our healthy very active 7 yr old blue tick beagle did not make it - Frazier took his last breath on February 25 2021 - he only declined the seizures continued he was fatigued all the time started losing control of his bladder - and losing his balance and walking in circles we kept hoping that once the poison was out of him he would improve but sadly he only declined I spent many nites sitting with him because the seizures were getting so bad - we tried everything but our vet tried with us but on Feb 25th our vet said that Frazier had enough and he would not recover - I did contact the company as my vet recommended and the worst customer service reps especially in this situation all they wanted was his vet records in a very matter of fact tone as I kindly replied in southern style - kiss my biscuits!! You ask why they are giving this poison to our furbabies, it's easy. The third ingredient in Simparica Trio is pyrantel. 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